Objective: To study the correlation between trough concentration (Cmin) of vancomycin

ratio of 24-hour drug time area under the curve (AUC24) and minimal inhibitory concentration (MIC)

and clinical outcome in children with orthopedic infection induced by methicillin-resistant Staphylococcus aureus (MRSA). Methods: Children with orthopedic infection induced by MRSA who received vancomycin in Foshan Hospital of Traditional Chinese Medicine from Jan. 2015 to Jun. 2020 were selected as the research objects. General information

clinical efficacy

Cmin of vancomycin

AUC24 and MIC were collected. Correlation between different Cmin of vancomycin interval

AUC24/MIC interval and clinical efficacy and incidence of adverse drug reactions was analyzed. Receiver operating characteristic (ROC) curve was used to study the correlation between Cmin and AUC24/MIC and clinical efficacy. Results: A total of 30 children were enrolled. There was no significant difference in the cure rate between the Cmin >10 mg/L group (66.67%) and the Cmin <10 mg/L group (48.15%

P>0.05). The cure rate of AUC24/MIC ≥400 group was 81.82%

significantly higher than 31.58% of AUC24/MIC <400 group (P<0.05). In the ROC curve

the area (0.92) under the ROC curve of Cmin was larger. There was no significant difference in the incidence of adverse drug reactions among different Cmin of vancomycin groups (P>0.05). Conclusion: Cmin of vancomycin ≥10 mg/L in children with orthopedic infection induced by MRSA is not necessary for optimal efficacy

yet Cmin of vancomycin need to be maintained above 5.25 mg/L. To ensure efficacy

AUC24/MIC ≥400 is necessary. However

the sample size in this study is small and the optimal Cmin still needs further validation.